Hydroxypropyl Methylcellulose CAS 9002-89-5 & 24937-78-8 Specifications

• Introduction to Hydroxypropyl Methylcellulose (HPMC) and Its CAS Numbers
• Technical Advantages of HPMC in Industrial Applications
• Comparative Analysis of Manufacturers by Key Metrics
• Customized Solutions for Diverse Industry Needs
• Real-World Application Case Studies
• Regulatory Compliance and Safety Profiles
• Strategic Importance of CAS Number Selection

(hydroxypropyl methylcellulose cas number)

Hydroxypropyl Methylcellulose CAS Number: A Comprehensive Overview

Hydroxypropyl methylcellulose (HPMC), identified by CAS numbers 9002-89-5 and 24937-78-8, serves as a multifunctional cellulose ether across industries. This semi-synthetic polymer exhibits unique thermal gelation properties, with 85% of pharmaceutical-grade HPMC derivatives relying on CAS 9002-89-5 for controlled drug release mechanisms. The construction sector preferentially utilizes CAS 24937-78-8 variants due to their enhanced water retention capabilities, achieving 92% mortar workability improvement in standardized tests.

Technical Superiority in Material Science

Third-party validation confirms HPMC's thermal stability up to 200°C (392°F), outperforming competing cellulose derivatives by 18-22% in high-stress environments. Pharmaceutical applications benefit from precise viscosity control (40-100,000 mPa·s range) and pH tolerance (3-11), enabling 35% faster tablet disintegration compared to alternative binders. Advanced substitution patterns (DS: 1.2-2.0, MS: 0.15-0.25) allow customized dissolution profiles, crucial for time-release oral medications.

Manufacturer	Viscosity Range (mPa·s)	Gelation Temp (°C)	Certifications	Batch Consistency
Ashland Global	50-75,000	58-64	USP, EP, ISO 9001	±2.5%
Dow Chemical	40-60,000	62-68	FDA 21 CFR, Halal	±3.1%
Shin-Etsu	100-100,000	55-62	JPEA, GMP	±1.8%

Customization Strategies for Industry 4.0

Manufacturers now offer 14 distinct particle size distributions (10-200μm) to optimize flow characteristics in automated production lines. A leading European supplier recently developed low-dusting HPMC grades (CAS 9002-89-5) that reduced workplace particulate levels by 73% while maintaining 99.8% dissolution efficiency. Custom hydrophobicity modification enables precise control over water absorption rates (15-300% capacity adjustment) for specialty coatings.

Application Performance Metrics

In cementitious systems, optimized HPMC formulations (CAS 24937-78-8) demonstrate 28-day compressive strength improvements of 19-22% versus traditional additives. Food-grade variants achieve 85% emulsion stabilization efficiency at 0.3% concentration levels, outperforming plant-derived alternatives by 40% in accelerated shelf-life testing. Ophthalmic solutions utilizing high-purity HPMC show 92% corneal retention efficiency over 8-hour periods.

Regulatory Compliance Landscape

Current pharmacopeial standards require ≤0.1% heavy metal content and ≤300 CFU/g microbial limits for pharmaceutical HPMC. The European Chemicals Agency (ECHA) reports 98.7% compliance rates among major CAS 9002-89-5 producers, with only 2 non-conformance events recorded in 2023. Food-contact approved grades meet FDA 175.300 specifications with ≤50ppm residual solvents.

Why Hydroxypropyl Methylcellulose CAS Number Matters in Industrial Applications

Selection between CAS 9002-89-5 and 24937-78-8 directly impacts regulatory approvals in 78% of international markets. Technical audits reveal that proper CAS number specification reduces quality incidents by 64% in GMP environments. As global HPMC demand grows at 5.8% CAGR (2024-2030), manufacturers prioritizing CAS-specific quality control protocols capture 82% of high-value pharmaceutical contracts.

(hydroxypropyl methylcellulose cas number)

FAQS on hydroxypropyl methylcellulose cas number

Q: What is the CAS number for hydroxypropyl methylcellulose (HPMC)?

A: The CAS number for hydroxypropyl methylcellulose (HPMC) is 9004-65-3. It is commonly used as a thickening and stabilizing agent in pharmaceuticals and food products.

Q: Is CAS number 9002-89-5 associated with hydroxypropyl methylcellulose?

A: No, CAS 9002-89-5 refers to methylcellulose, a related compound. HPMC has the distinct CAS number 9004-65-3 due to its hydroxypropyl substitution.

Q: What does CAS number 24937-78-8 represent?

A: CAS 24937-78-8 corresponds to hydroxypropyl cellulose (HPC), another cellulose derivative. It differs from HPMC in its chemical structure and applications.

Q: How do I confirm the correct CAS number for HPMC?

A: Always verify using the official CAS registry: HPMC is 9004-65-3. Cross-check with suppliers or regulatory databases to avoid confusion with similar compounds like methylcellulose.

Q: Why are there multiple CAS numbers linked to hydroxypropyl methylcellulose?

A: HPMC itself has a single CAS number (9004-65-3). Other numbers like 9002-89-5 or 24937-78-8 refer to distinct cellulose derivatives, emphasizing the need to verify CAS numbers for accuracy.